Synthesis of 5-fluoroisatin and 7-fluoroisatin Thiosemicarbazone Ligands

Abstract

Isatin thiosemicarbazones have been known for a long time to have biological properties such as in the production of anti-tuberculosis drugs. Recently they have been used in the synthesis of metal complexes. We have investigated the synthesis and characterization of the 5-fluoroisatin and 7-fluoroisatin thiosemicarbazones. This poster presents information on synthesis and NMR characterization of the ligands to form Pd(II) complexes.