Synthesis and NMR Characterization of Mixed Oxime Thiosemicarbazones and their Metal Complexes

Abstract

Thiosemicarbazones are a class of organic compounds that function extremely well as ligands that bind to transition metals to form metal complexes with interesting biological properties. This presentations focuses on synthesis and characterization of a new series of monoxime thiosemicarbazone. Two new compounds, namely a-isonitrosacetophenone ethyl thiosemicarbazone (INAP-ETSC) and a-isonitrosacetophenone tert-butyl thiosemicarbazone (INAP-tButyl), are synthesized and characterized by Nuclear Magentic Resonance Spectroscopy (NMR). The synthesized compounds were further used to create metal-ligand complexes that will be tested for their anticancer properties by studying the inhibition of topoisomerase IIa.