*WINNER* Synthesis of a novel Terpenoid and optimization of its preparation for yield and environmental impact using Design of Experiment (DOE)

Abstract

The use of certain solvents in chemical reactions can cause negative environmental impacts. The goal of this work is to synthesize a novel terpenoid for use as topoisomerase inhibitors and optimize this synthesis for both yield and environmental impacts. The reactions are analyzed by a green scoring software, DOZN, that provides a quantitative scoring of its environmental impact. This research optimized a green reaction on the microliter scale using design of experiment (DOE) procedures with nuclear magnetic resonance (NMR). The reporting of the synthesis of a terpene derivative including an F19 label and the optimization of its synthesis using DOE for its ideal DOZN score. A standard procedure that optimizes multiple reactions while also remaining fiscally competitive with non-green alternatives was developed.