Synthesis of Pyruvaldehyde Thiosemicarbazone (TSC) Metal Complexes and Their NMR Spectrum Data

  • Adam Koch


For years Copper-PTSM, a metal TSC derivative, has been used for brain imaging scans and has been a useful in anti-tumor research. This work consists of synthesizing derivatives of TSC and their respective Ni, Pt, Pd metal complexes through a synthesis reaction. The ligands and metal complexes are then prepared for NMR spectrum analysis. Four different NMR spectra are run (1H, 13C, C and N HSQC) to evaluate the purity and conversion of reactants to the desired products. Analysis of NMR spectra will assist in determination of the symmetry or asymmetry of these products. Initial synthesis and in-depth evaluation of NMR data will be presented.