Synthesis, NMR Analysis, and Copper Complex Formation of INAP-TSC compounds

Abstract

This poster will present the synthesis and characterization by Nuclear Magnetic Resonance (NMR) spectroscopy of a new series of thiosemicarbazone molecules. We have successfully synthesized the INAP-TSC compounds using α-Isonitrosoacetophenone and an appropriate thiosemicarbazide. This research has experimented with different reaction procedures in the hope of finding the cleanest and most efficient synthesis route. Our use of NMR has enabled us to determine the most appropriate synthesis procedures to ensure the cleanest products. After finding the best synthesis procedure, we have begun making new copper-complex molecules using these synthesized thiosemicarbazones. We then tested these copper-complexes for their ability to inhibit topoisomerase activity. New thiosemicarbazone ligands are important in designing new anti-cancer drugs. This research is providing new molecules for testing against breast cancer cells in the future.