*WINNER* Synthesis of INAP-ETSC and INAP-tButyl

Abstract

Thiosemicarbazenes are a class of organic compounds that function extremely well as ligands that bind to transition metals to form metal complexes with interesting biological properties. This presentation focuses on synthesis and characterization of a new series of monoxime thiosemicarbozone. Two new compounds, namely α-isonitrosacetophenone ethyl thiosemicarbozone (INAP-ETSC) and α-isonitrosacetophenone tert-butyl thiosemicarbozone (INAP-tButyl), are synthesized and characterized by Nuclear Magnetic Resonance Spectroscopy (NMR). The synthesized compounds are further used to create the palladium-ligand complexes that can be tested for their anticancer properties by studying the inhibition of topo-isomerase 2ɑ.