Utilizing 1H-NMR spectroscopy to measure the octanol-water partition coefficient of hydantoin compounds

Abstract

Solid-state drugs exhibit polymorphism (transformations between crystalline structures), negatively impacting their solubility, bioavailability, and overall efficacy. These changes can be prevented by transforming these drugs into an ionic liquid state. Hydantoin drugs were initially used as antiseizure and antiepileptic medications. After additional investigation, their topical use as a treatment for chronic wounds has shown promise. Their solubility impacts their efficacy in wound fluid. Previous research has shown that these compounds can successfully be converted into liquid state through the ionic liquid approach. Gaining insight into the dissolution rates of these compounds allows for new delivery pathways to be investigated. Their hydrophilic and hydrophobic properties can be determined by calculating the octanol-water partition coefficient (Kow). Here our efforts evaluating these properties through the use of 1H-NMR spectroscopy are discussed.