Synthesis of 2-acetyl-thiazole thiosemicarbazone ligands and their characterization by NMR spectroscopy.

Abstract

A new series of 2-acetyl-thiazole thiosemicarbazone (ATZ-TSC) ligands were synthesized. The 2-acetyl-thiazole ligands were synthesized with the following series of substituents: methyl thiosemicarbazone, ethyl thiosemicarbazone, tert-butyl thiosemicarbazone, benzyl thiosemicarbazone, and phenyl thiosemicarbazone. After the synthesis, the compounds were characterized by NMR spectroscopy. Four NMR experiments were performed: 1H, 13C, 1H-15N, and 1H-13C. The NMR experimental results provide evidence for the ligands’ proposed structures. We also have acquired minimum inhibitory concentration (MIC) data on seven different microbes (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Aspergillus niger, Candida albicans, and Saccharomyces cerevisiae) for the new series of ligands. Several of the compounds, particularly the ATZ-tBTSC and ATZ-ETSC had anti-proliferative behavior.