Effect of Thiosemicarbazone Complexes as Anticancer Agents on In-Vitro Cancer Cell-Lines

Abstract

Thiosemicarbazone metal complexes were synthesized in the lab and their effects as anticancer agents—in respect to their inhibition with Topoisomerase II within the cell genome—were observed. Breast cancer cell-lines MDA-231 and HCF-7 were extracted into medium, and allowed to replicate in vitro. We then implement thiosemicarbazone metal complexes within the cell-lines to observe effects on cells and whether or not they work as anticancer agents. The purpose is to be able to implement such metal complexes in vivo in order to witness these effects on cancer cells in patients suffering from breast cancer.Thiosemicarbazone metal complexes were synthesized in the lab and their effects as anticancer agents—in respect to their inhibition with Topoisomerase II within the cell genome—were observed. Breast cancer cell-lines MDA-231 and HCF-7 were extracted into medium, and allowed to replicate in vitro. We then implement thiosemicarbazone metal complexes within the cell-lines to observe effects on cells and whether or not they work as anticancer agents. The purpose is to be able to implement such metal complexes in vivo in order to witness these effects on cancer cells in patients suffering from breast cancer.