Synthesis and characterization of 2-acetylpyrazine-tert-butylthiosemicarbazone, and its palladium (II) complex, [Pd(APZ-tBTSC)Cl].

Abstract

The new ligand, 2-acetylpyrazine-tert-butylthiosemicarbazone (APT-tBTSC) and its palladium (II) complex have been synthesized. After the synthesis process, the ligand and Pd complex were characterized and analyzed by 1H Nuclear Magnetic Resonance spectrometry (NMR), 13C NMR, 1H-13C HSQC, and 1H-15N HSQC. The acronym HSQC stands for Heteronuclear Single Quantum Coherence. We have determined that this thiosemicarbazone compound ligates to Pd in a tridentate monoanionic fashion forming a metal complex with the formula [Pd(APZ-tBTSC)Cl]. The metal complex was tested for biological behavior with a panel of seven microbes. The palladium complex was found to be highly active against Gram positive bacteria.